BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation

Cathepsin K inhibitor (odanacatib; ODN) and cathepsin K knockdown (siRNA) enhance oxaliplatin-induced apoptosis through p53-dependent Bax upregulation. However, its underlying mechanisms remain unclear. In this study, we elucidated the mechanism behind enhancement of oxaliplatin-induced apoptosis by...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Seung Un Seo, Seon Min Woo, Seul Gi Lee, Min Yeong Kim, Hyun Shik Lee, Yung Hyun Choi, Sang Hyun Kim, Young-Chae Chang, Kyoung-jin Min, Taeg Kyu Kwon
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-07-01
Colecção:Redox Biology
Assuntos:
Odanacatib
Bax
p53
Sp1
BAP1
Mitochondrial ROS
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231722001082
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados