Synaptic dysfunction in human neurons with autism-associated deletions in PTCHD1-AS

BACKGROUND: The Xp22.11 locus that encompasses PTCHD1, DDX53, and the long noncoding RNA (lncRNA) PTCHD1-AS is frequently disrupted in males with autism spectrum disorder (ASD), but the functional consequences of these genetic risk factors for ASD are unknown. METHODS: To evaluate the functional con...

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Vydáno v:Biol Psychiatry
Hlavní autoři: Ross, P. Joel, Zhang, Wen-Bo, Mok, Rebecca S.F., Zaslavsky, Kirill, Deneault, Eric, D’Abate, Lia, Rodrigues, Deivid C., Yuen, Ryan K.C., Faheem, Muhammad, Mufteev, Marat, Piekna, Alina, Wei, Wei, Pasceri, Peter, Landa, Rebecca J., Nagy, Andras, Varga, Balazs, Salter, Michael W., Scherer, Stephen W., Ellis, James
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948145/
https://ncbi.nlm.nih.gov/pubmed/31540669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2019.07.014
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