SHANK2 mutations associated with Autism Spectrum Disorder cause hyperconnectivity of human neurons

Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum disorder (ASD). We generated cortical neurons from induced pluripotent stem cells (iPSC) derived from neurotypic and ASD-affected donors. We developed Sparse coculture for Connectivity (SparCon) assays where SHANK2...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Neurosci
Hlavní autoři: Zaslavsky, Kirill, Zhang, Wen-Bo, McCready, Fraser P., Rodrigues, Deivid C., Deneault, Eric, Loo, Caitlin, Zhao, Melody, Ross, P. Joel, Hajjar, Joelle El, Romm, Asli, Thompson, Tadeo, Piekna, Alina, Wei, Wei, Wang, Zhuozhi, Khattak, Shahryar, Mufteev, Marat, Pasceri, Peter, Scherer, Stephen W., Salter, Michael W., Ellis, James
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475597/
https://ncbi.nlm.nih.gov/pubmed/30911184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0365-8
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky