SHANK2 mutations associated with Autism Spectrum Disorder cause hyperconnectivity of human neurons

Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum disorder (ASD). We generated cortical neurons from induced pluripotent stem cells (iPSC) derived from neurotypic and ASD-affected donors. We developed Sparse coculture for Connectivity (SparCon) assays where SHANK2...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Zaslavsky, Kirill, Zhang, Wen-Bo, McCready, Fraser P., Rodrigues, Deivid C., Deneault, Eric, Loo, Caitlin, Zhao, Melody, Ross, P. Joel, Hajjar, Joelle El, Romm, Asli, Thompson, Tadeo, Piekna, Alina, Wei, Wei, Wang, Zhuozhi, Khattak, Shahryar, Mufteev, Marat, Pasceri, Peter, Scherer, Stephen W., Salter, Michael W., Ellis, James
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475597/
https://ncbi.nlm.nih.gov/pubmed/30911184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0365-8
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