Synaptic dysfunction in human neurons with autism-associated deletions in PTCHD1-AS

BACKGROUND: The Xp22.11 locus that encompasses PTCHD1, DDX53, and the long noncoding RNA (lncRNA) PTCHD1-AS is frequently disrupted in males with autism spectrum disorder (ASD), but the functional consequences of these genetic risk factors for ASD are unknown. METHODS: To evaluate the functional con...

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Publicado no:Biol Psychiatry
Main Authors: Ross, P. Joel, Zhang, Wen-Bo, Mok, Rebecca S.F., Zaslavsky, Kirill, Deneault, Eric, D’Abate, Lia, Rodrigues, Deivid C., Yuen, Ryan K.C., Faheem, Muhammad, Mufteev, Marat, Piekna, Alina, Wei, Wei, Pasceri, Peter, Landa, Rebecca J., Nagy, Andras, Varga, Balazs, Salter, Michael W., Scherer, Stephen W., Ellis, James
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948145/
https://ncbi.nlm.nih.gov/pubmed/31540669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2019.07.014
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