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A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma

A cogent issue in cancer research is how to account for the effects of tumor microenvironment (TME) on the response to therapy, warranting the need to adopt adequate in vitro and in vivo models. This is particularly relevant in the development of strategies targeting cancer metabolism, as they will...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Med
Hauptverfasser: Kurelac, Ivana, Abarrategi, Ander, Ragazzi, Moira, Iommarini, Luisa, Ganesh, Nikkitha Umesh, Snoeks, Thomas, Bonnet, Dominique, Porcelli, Anna Maria, Malanchi, Ilaria, Gasparre, Giuseppe
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6947153/
https://ncbi.nlm.nih.gov/pubmed/31835761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm8122184
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