NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate

Complex I (CI) is the largest enzyme of the mitochondrial respiratory chain, and its defects are the main cause of mitochondrial disease. To understand the mechanisms regulating the extremely intricate biogenesis of this fundamental bioenergetic machine, we analyze the structural and functional cons...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: D’Angelo, Luigi, Astro, Elisa, De Luise, Monica, Kurelac, Ivana, Umesh-Ganesh, Nikkitha, Ding, Shujing, Fearnley, Ian M., Gasparre, Giuseppe, Zeviani, Massimo, Porcelli, Anna Maria, Fernandez-Vizarra, Erika, Iommarini, Luisa
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076766/
https://ncbi.nlm.nih.gov/pubmed/33882309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109002
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