Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

Converting carcinomas in benign oncocytomas has been suggested as a potential anti-cancer strategy. One of the oncocytoma hallmarks is the lack of respiratory complex I (CI). Here we use genetic ablation of this enzyme to induce indolence in two cancer types, and show this is reversed by allowing th...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Kurelac, Ivana, Iommarini, Luisa, Vatrinet, Renaud, Amato, Laura Benedetta, De Luise, Monica, Leone, Giulia, Girolimetti, Giulia, Umesh Ganesh, Nikkitha, Bridgeman, Victoria Louise, Ombrato, Luigi, Columbaro, Marta, Ragazzi, Moira, Gibellini, Lara, Sollazzo, Manuela, Feichtinger, Rene Gunther, Vidali, Silvia, Baldassarre, Maurizio, Foriel, Sarah, Vidone, Michele, Cossarizza, Andrea, Grifoni, Daniela, Kofler, Barbara, Malanchi, Ilaria, Porcelli, Anna Maria, Gasparre, Giuseppe
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385215/
https://ncbi.nlm.nih.gov/pubmed/30796225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08839-1
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires