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PD-1 expression during acute infection is repressed through a LSD1- Blimp-1 axis

During prolonged exposure to antigens, such as chronic viral infections, sustained TCR signaling can result in T cell exhaustion mediated in part by expression of Programmed cell death-1 (PD-1) encoded by the Pdcd1 gene. Here, dynamic changes in histone H3K4 modifications at the Pdcd1 locus during e...

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Foilsithe in:J Immunol
Main Authors: Bally, Alexander P. R., Neeld, Dennis K., Lu, Peiyuan, Majumder, Parimal, Tang, Yan, Barwick, Benjamin G., Wang, Qing, Boss, Jeremy M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946872/
https://ncbi.nlm.nih.gov/pubmed/31811020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900601
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