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PD-1 expression during acute infection is repressed through a LSD1- Blimp-1 axis
During prolonged exposure to antigens, such as chronic viral infections, sustained TCR signaling can result in T cell exhaustion mediated in part by expression of Programmed cell death-1 (PD-1) encoded by the Pdcd1 gene. Here, dynamic changes in histone H3K4 modifications at the Pdcd1 locus during e...
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| Udgivet i: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6946872/ https://ncbi.nlm.nih.gov/pubmed/31811020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900601 |
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