Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Bone remodeling consists of resorption by osteoclasts followed by formation by osteoblasts, and osteoclasts are a source of bone formation-stimulating factors. Here we utilize osteoclast ablation by denosumab (DMAb) and RNA-sequencing of bone biopsies from postmenopausal women to identify osteoclast...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Weivoda, Megan M., Chew, Chee Kian, Monroe, David G., Farr, Joshua N., Atkinson, Elizabeth J., Geske, Jennifer R., Eckhardt, Brittany, Thicke, Brianne, Ruan, Ming, Tweed, Amanda J., McCready, Louise K., Rizza, Robert A., Matveyenko, Aleksey, Kassem, Moustapha, Andersen, Thomas Levin, Vella, Adrian, Drake, Matthew T., Clarke, Bart L., Oursler, Merry Jo, Khosla, Sundeep
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946812/
https://ncbi.nlm.nih.gov/pubmed/31911667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14003-6
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