Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours

BACKGROUND: Germ cell tumours (GCTs) represent a highly curable malignity as they respond well to cisplatin (CDDP)-based chemotherapy. Nevertheless, a small proportion of GCT patients relapse or do not respond to therapy. As this might be caused by an increased capacity to repair CDDP-induced DNA da...

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Pubblicato in:BMC Cancer
Autori principali: Cierna, Zuzana, Miskovska, Vera, Roska, Jan, Jurkovicova, Dana, Pulzova, Lucia Borszekova, Sestakova, Zuzana, Hurbanova, Lenka, Machalekova, Katarina, Chovanec, Michal, Rejlekova, Katarina, Svetlovska, Daniela, Kalavska, Katarina, Kajo, Karol, Babal, Pavel, Mardiak, Jozef, Ward, Thomas A., Mego, Michal, Chovanec, Miroslav
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945513/
https://ncbi.nlm.nih.gov/pubmed/31906898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6496-1
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