Interferon-β corrects massive gene dysregulation in multiple sclerosis: Short-term and long-term effects on immune regulation and neuroprotection

BACKGROUND: In multiple sclerosis (MS), immune up-regulation is coupled to subnormal immune response to interferon-β (IFN-β) and low serum IFN-β levels. The relationship between the defect in IFN signalling and acute and long-term effects of IFN-β on gene expression in MS is inadequately understood....

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Feng, Xuan, Bao, Riyue, Li, Lei, Deisenhammer, Florian, Arnason, Barry G.W., Reder, Anthony T.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945282/
https://ncbi.nlm.nih.gov/pubmed/31648992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.09.059
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