Aging induces an Nlrp3 inflammasome-dependent expansion of adipose B cells that impairs metabolic homeostasis

During aging visceral adiposity is often associated with alterations in adipose tissue (AT) leukocytes, inflammation and metabolic dysfunction. However, the contribution of AT B cells in immunometabolism during aging is unexplored. Here, we show that aging is associated with an expansion of a unique...

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Vydáno v:Cell Metab
Hlavní autoři: Camell, Christina D., Günther, Patrick, Lee, Aileen, Goldberg, Emily L., Spadaro, Olga, Youm, Yun-Hee, Bartke, Andrzej, Hubbard, Gene B., Ikeno, Yuji, Ruddle, Nancy H., Schultze, Joachim, Dixit, Vishwa Deep
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944439/
https://ncbi.nlm.nih.gov/pubmed/31735593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.10.006
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