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Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis in the aged

Catecholamine-induced lipolysis, the first step in generation of energy substrates through hydrolysis of triglycerides (TGs) (1), declines with age (2,3). The defect in mobilization of free fatty acids (FFA) in elderly is accompanied with increased visceral adiposity, lower exercise capacity, failur...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Camell, Christina D., Sander, Jil, Spadaro, Olga, Lee, Aileen, Nguyen, Kim Y., Wing, Allison, Goldberg, Emily L., Youm, Yun-Hee, Brown, Chester W., Elsworth, John, Rodeheffer, Matthew S., Schultze, Joachim L., Dixit, Vishwa Deep
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718149/
https://ncbi.nlm.nih.gov/pubmed/28953873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24022
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