Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence

The hallmarks of age-related immune senescence are chronic inflammation, aberrant expansion of effector memory, and loss of naive T lymphocytes due in part to systemic activation of innate immune sensor NLRP3 inflammasome in myeloid lineage cells. The endogenous mechanisms that regulate inflammasome...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Spadaro, Olga, Goldberg, Emily L., Camell, Christina D., Youm, Yun-Hee, Kopchick, John J., Nguyen, Kim Y., Bartke, Andrzej, Sun, Liou Y., Dixit, Vishwa Deep
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992590/
https://ncbi.nlm.nih.gov/pubmed/26876170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.01.044
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