OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

Down syndrome (DS) is a common neurodevelopmental disorder, and cognitive defects in DS patients may arise from imbalances in excitatory and inhibitory neurotransmission. Understanding the mechanisms underlying such imbalances may provide opportunities for therapeutic intervention. Here, we show tha...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Xu, Ranjie, Brawner, Andrew T., Li, Shenglan, Liu, Jing-Jing, Kim, Hyosung, Xue, Haipeng, Pang, Zhiping P., Kim, Woo-Yang, Hart, Ronald P., Liu, Ying, Jiang, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944064/
https://ncbi.nlm.nih.gov/pubmed/31130512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.04.014
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados