OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

Down syndrome (DS) is a common neurodevelopmental disorder, and cognitive defects in DS patients may arise from imbalances in excitatory and inhibitory neurotransmission. Understanding the mechanisms underlying such imbalances may provide opportunities for therapeutic intervention. Here, we show tha...

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Publicat a:Cell Stem Cell
Autors principals: Xu, Ranjie, Brawner, Andrew T., Li, Shenglan, Liu, Jing-Jing, Kim, Hyosung, Xue, Haipeng, Pang, Zhiping P., Kim, Woo-Yang, Hart, Ronald P., Liu, Ying, Jiang, Peng
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944064/
https://ncbi.nlm.nih.gov/pubmed/31130512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.04.014
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