Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of Nephronophthisis

Nephronophthisis (NPHP), the leading genetic cause of end-stage renal failure in children and young adults, is a group of autosomal recessive diseases characterized by kidney-cyst degeneration and fibrosis for which no therapy is currently available. To date, mutations in >25 genes have been iden...

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Publicado no:Am J Pathol
Main Authors: Jin, Heng, Zhang, Yan, Liu, Dingxiao, Wang, Shan Shanshan, Ding, Qiong, Rastogi, Prerna, Purvis, Madison, Wang, Angela, Elhadi, Sarah, Ren, Chongyu, Cao, Chao, Chai, Yanfen, Igarashi, Peter, Jetten, Anton M., Lu, Dongmei, Attanasio, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943802/
https://ncbi.nlm.nih.gov/pubmed/31676329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.09.013
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