Investigating the Binding Mode of Reversible LSD1 Inhibitors Derived from Stilbene Derivatives by 3D-QSAR, Molecular Docking, and Molecular Dynamics Simulation

Overexpression of lysine specific demethylase 1 (LSD1) has been found in many cancers. New anticancer drugs targeting LSD1 have been designed. The research on irreversible LSD1 inhibitors has entered the clinical stage, while the research on reversible LSD1 inhibitors has progressed slowly so far. I...

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Publicado no:Molecules
Main Authors: Xu, Yongtao, He, Zihao, Yang, Min, Gao, Yunlong, Jin, Linfeng, Wang, Meiting, Zheng, Yichao, Lu, Xiaoyuan, Zhang, Songjie, Wang, Chang, Zhao, Zongya, Zhao, Junqiang, Gao, Qinghe, Duan, Yingchao
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943670/
https://ncbi.nlm.nih.gov/pubmed/31817721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244479
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