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Molecular modelling studies of quinazolinone derivatives as MMP-13 inhibitors by QSAR, molecular docking and molecular dynamics simulations techniques

Matrix metalloproteinase-13 (MMP-13) is an attractive drug target for the treatment of osteoarthritis (OA). In this study, a series of quinazolinone derivatives as MMP-13 inhibitors were firstly systematically studied using QSAR, molecular docking and molecular dynamics (MD) simulation. The reliable...

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Vydáno v:Medchemcomm
Hlavní autoři: Huang, Shanshan, Feng, Kairui, Ren, Yujie
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350765/
https://ncbi.nlm.nih.gov/pubmed/30774858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00375k
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