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Determination of Chemical Stability of Two Oral Antidiabetics, Metformin and Repaglinide in the Solid State and Solutions Using LC-UV, LC-MS, and FT-IR Methods

Firstly, metformin and repaglinide were degraded under high temperature/humidity, UV/VIS light, in different pH and oxidative conditions. Secondly, a new validated LC-UV method was examined, as to whether it validly determined these drugs in the presence of their degradation products and whether it...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Gumieniczek, Anna, Berecka-Rycerz, Anna, Mroczek, Tomasz, Wojtanowski, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943551/
https://ncbi.nlm.nih.gov/pubmed/31817112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244430
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