A combination of low-dose decitabine and chidamide resulted in synergistic effects on the proliferation and apoptosis of human myeloid leukemia cell lines

Two of the most common and well-characterized epigenetic changes, DNA methylation and histone modifications, occur in leukemia. Decitabine (5-aza-2’-deoxycytidine, DAC), as a hypomethylating agent (HMA), and chidamide (CS055), as a histone deacetylase inhibitor (HDACi), each demonstrate effects agai...

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發表在:Am J Transl Res
Main Authors: Xu, Fangfang, Guo, Honggang, Shi, Mingyue, Liu, Siwei, Wei, Min, Sun, Kai, Chen, Yuqing
格式: Artigo
語言:Inglês
出版: e-Century Publishing Corporation 2019
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943475/
https://ncbi.nlm.nih.gov/pubmed/31934307
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