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Regulation of cartilage damage caused by lack of Klotho with thioredoxin/peroxiredoxin (Trx/Prx) system and succedent NLRP3 activation in osteoarthritis mice

This present study aims to verify the underlying mechanism that anti-aging protein Klotho protects cartilages against the damage induced by oxidative stress. The Klotho expression level in the articular cartilages of mice with osteoarthritis (OA) was measured by using western blotting and quantitati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Am J Transl Res
Hauptverfasser: Gu, Yanqing, Ren, Kewei, Jiang, Chunzhi, Wang, Liming, Yao, Qingqiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943451/
https://ncbi.nlm.nih.gov/pubmed/31934282
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