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Melarsomine suppresses canine osteosarcoma cell survival via inhibition of Hedgehog-GLI signaling
The Hedgehog-GLI signaling pathway is activated in human and canine osteosarcoma (OSA) and represents a potential therapeutic target for cancers, including OSA. Arsenic trioxide represses GLI expression. Melarsomine, an arsenic compound-containing drug, has been approved for the treatment of canine...
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| Pubblicato in: | J Vet Med Sci |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Japanese Society of Veterinary Science
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6943322/ https://ncbi.nlm.nih.gov/pubmed/31645504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1292/jvms.19-0043 |
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