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Blocking Signaling at the Level of GLI Regulates Downstream Gene Expression and Inhibits Proliferation of Canine Osteosarcoma Cells

The Hedgehog-GLI signaling pathway is active in a variety of human malignancies and is known to contribute to the growth and survival of human osteosarcoma cells. In this study, we examined the expression and regulation of GLI transcription factors in multiple canine osteosarcoma cell lines and anal...

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Bibliografski detalji
Glavni autori: Shahi, Mehdi Hayat, Holt, Roseline, Rebhun, Robert B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014515/
https://ncbi.nlm.nih.gov/pubmed/24810746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096593
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