Ablation of Cytochrome c in Adult Forebrain Neurons Impairs Oxidative Phosphorylation Without Detectable Apoptosis

Cytochrome c (Cyt c), a heme-containing mitochondrial protein, has a critical function in both respiration and apoptosis. Consistent with these vital functions, somatic Cyt c mouse knockout is embryonic lethal. In order to investigate the sensitivity of postnatal neurons to Cyt c depletion, we devel...

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Vydáno v:Mol Neurobiol
Hlavní autoři: Pinto, Milena, Vempati, Uma D., Diaz, Francisca, Peralta, Susana, Moraes, Carlos T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942697/
https://ncbi.nlm.nih.gov/pubmed/30191381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1335-y
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