Pembrolizumab in combination with the oncolytic virus pelareorep and chemotherapy in patients with advanced pancreatic adenocarcinoma: a Phase 1b study

BACKGROUND: Pelareorep is an intravenously delivered oncolytic reovirus that can induce a T cell-inflamed phenotype in pancreatic ductal adenocarcinoma (PDAC). Tumor tissues from patients treated with pelareorep have shown reovirus replication, T-cell infiltration, and upregulation of PD-L1. We hypo...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Mahalingam, Devalingam, Wilkinson, Grey A, Eng, Kevin H., Fields, Paul, Raber, Patrick, Moseley, Jennifer L., Cheetham, Karol, Coffey, Matt, Nuovo, Gerard, Kalinski, Pawel, Zhang, Bin, Arora, Sukeshi Patel, Fountzilas, Christos
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942612/
https://ncbi.nlm.nih.gov/pubmed/31694832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2078
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