TTC5 mediates autoregulation of tubulin via mRNA degradation

Tubulins play crucial roles in cell division, intracellular traffic, and cell shape. Tubulin concentration is autoregulated by feedback control of mRNA degradation via an unknown mechanism. Here, we identified tetratricopeptide protein 5 (TTC5) as a tubulin-specific ribosome-associating factor that...

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Udgivet i:Science
Main Authors: Lin, Zhewang, Gasic, Ivana, Chandrasekaran, Viswanathan, Peters, Niklas, Shao, Sichen, Mitchison, Timothy J., Hegde, Ramanujan S.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942541/
https://ncbi.nlm.nih.gov/pubmed/31727855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz4352
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