Formation of (2R)- and (2S)-8-Prenylnaringenin Glucuronides by Human UDP-Glucuronosyltransferases

Occurring in hops (Humulus lupulus) and beer as a racemic mixture, (2R,2S)-8-prenylnaringenin (8-PN) is a potent phytoestrogen in hop dietary supplements used by women as alternatives to conventional hormone therapy. With a half-life exceeding 20 h, 8-PN is excreted primarily as 8-PN-7-O-glucuronide...

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Detalhes bibliográficos
Publicado no:J Agric Food Chem
Main Authors: Fang, Jin-Bo, Nikolić, Dejan, Lankin, David C, Simmler, Charlotte, Chen, Shao-Nong, Ramos Alvarenga, Rene F., Liu, Yang, Pauli, Guido F., van Breemen, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942495/
https://ncbi.nlm.nih.gov/pubmed/31554401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jafc.9b04657
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