Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagy

BACKGROUND: The functions of HULC have been demonstrated in several cancers. However, its mechanism has not been elucidated in human liver cancer stem cells. METHODS: Liver cancer stem cells were isolated from Huh7 cells; gene infection and tumorigenesis test in vitro and in vivo were performed. RES...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Wang, Chen, Jiang, Xiaoxue, Li, Xiaonan, Song, Shuting, Meng, Qiuyu, Wang, Liyan, Lu, Yanan, Xin, Xiaoru, Pu, Hu, Gui, Xin, Li, Tianming, Lu, Dongdong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942366/
https://ncbi.nlm.nih.gov/pubmed/31900225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1528-y
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