Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN

Maternally expressed gene 3 (MEG3) encodes an lncRNA which is suggested to function as a tumor suppressor and has been showed to involve in a variety of cancers. Herein, our findings demonstrate that MEG3 inhibits the malignant progression of liver cancer cells in vitro and in vivo. Mechanistically,...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zheng, Qidi, Lin, Zhuojia, Xu, Jie, Lu, Yanan, Meng, Qiuyu, Wang, Chen, Yang, Yuxin, Xin, Xiaoru, Li, Xiaonan, Pu, Hu, Gui, Xin, Li, Tianming, Xiong, Wujun, Lu, Dongdong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833746/
https://ncbi.nlm.nih.gov/pubmed/29449541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0305-7
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