Inhibition of the Keap1-Nrf2 protein-protein interaction protects retinal cells and ameliorates retinal ischemia-reperfusion injury

The Nrf2-Keap1 pathway regulates transcription of a wide array of antioxidant and cytoprotective genes and offers critical protection against oxidative stress. This pathway has demonstrated benefit for a variety of retinal conditions. Retinal ischemia plays a pivotal role in many vision threatening...

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Pubblicato in:Free Radic Biol Med
Autori principali: Hui, Qiaoyan, Karlstetter, Marcus, Xu, Zhenhua, Yang, Jing, Zhou, Lingli, Eilken, Hanna M., Terjung, Carsten, Cho, Hongkwan, Gong, Junsong, Lai, Michael J., Nassar, Khaled, Duh, Elia J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942228/
https://ncbi.nlm.nih.gov/pubmed/31669760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.10.414
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