Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Replicable genetic association signals have consistently been found through genome-wide association studies in recent years. The recent dramatic expansion of study sizes improves power of estimation of effect sizes, genomic prediction, causal inference, and polygenic selection, but it simultaneously...

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Dades bibliogràfiques
Publicat a:Hum Genet
Autors principals: Lawson, Daniel John, Davies, Neil Martin, Haworth, Simon, Ashraf, Bilal, Howe, Laurence, Crawford, Andrew, Hemani, Gibran, Davey Smith, George, Timpson, Nicholas John
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2019
Matèries:
Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942007/
https://ncbi.nlm.nih.gov/pubmed/31030318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-019-02014-8
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