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Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

Large studies use genotype data to discover genetic contributions to complex traits and infer relationships between those traits. Co-incident geographical variation in genotypes and health traits can bias these analyses. Here we show that single genetic variants and genetic scores composed of multip...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Haworth, Simon, Mitchell, Ruth, Corbin, Laura, Wade, Kaitlin H., Dudding, Tom, Budu-Aggrey, Ashley, Carslake, David, Hemani, Gibran, Paternoster, Lavinia, Smith, George Davey, Davies, Neil, Lawson, Daniel J., J. Timpson, Nicholas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338768/
https://ncbi.nlm.nih.gov/pubmed/30659178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08219-1
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