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Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
Replicable genetic association signals have consistently been found through genome-wide association studies in recent years. The recent dramatic expansion of study sizes improves power of estimation of effect sizes, genomic prediction, causal inference, and polygenic selection, but it simultaneously...
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| Publicado no: | Hum Genet |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6942007/ https://ncbi.nlm.nih.gov/pubmed/31030318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-019-02014-8 |
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