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Preparation of a New Construct of Human Histone Deacetylase 8 for the Crystallization of Enzyme-Inhibitor Complexes

The metal-dependent histone deacetylases (HDACs) are critical regulatory enzymes that modulate myriad cellular processes. Implicated in cancer, neurodegenerative diseases, and other clinical disorders, various HDAC isozymes serve as validated drug targets. However, structural similarities among the...

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Bibliografiske detaljer
Udgivet i:Methods Enzymol
Main Authors: Porter, Nicholas J., Christianson, David W.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941479/
https://ncbi.nlm.nih.gov/pubmed/31606091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2019.06.029
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