Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

In mammalian cells, >25% of synthesized proteins are exported through the secretory pathway. The pathway complexity, however, obfuscates its impact on the secretion of different proteins. Unraveling its impact on diverse proteins is particularly important for biopharmaceutical production. Here we...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas B., Hefzi, Hooman, Grav, Lise M., Ley, Daniel, Baycin Hizal, Deniz, Betenbaugh, Michael J., Voldborg, Bjorn, Faustrup Kildegaard, Helene, Min Lee, Gyun, Palsson, Bernhard O., Nielsen, Jens, Lewis, Nathan E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940358/
https://ncbi.nlm.nih.gov/pubmed/31896772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13867-y
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