Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition

The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs). Moreover, in humans, the gut microbiota converts the primary BAs,...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Honda, Akira, Miyazaki, Teruo, Iwamoto, Junichi, Hirayama, Takeshi, Morishita, Yukio, Monma, Tadakuni, Ueda, Hajime, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Ikegami, Tadashi
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939601/
https://ncbi.nlm.nih.gov/pubmed/31645370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000395
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