Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

Alterations of the tumor suppressor gene TP53 are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia (ALL), TP53 mutations are infrequent but enriched at relapse. As in most cancers, mainly DNA-binding domain missense mutations are found, res...

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Publicat a:Haematologica
Autors principals: Demir, Salih, Boldrin, Elena, Sun, Qian, Hampp, Stephanie, Tausch, Eugen, Eckert, Cornelia, Ebinger, Martin, Handgretinger, Rupert, te Kronnie, Geertruy, Wiesmüller, Lisa, Stilgenbauer, Stephan, Selivanova, Galina, Debatin, Klaus-Michael, Meyer, Lüder Hinrich
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939517/
https://ncbi.nlm.nih.gov/pubmed/31073076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.199364
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