Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

Alterations of the tumor suppressor gene TP53 are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia (ALL), TP53 mutations are infrequent but enriched at relapse. As in most cancers, mainly DNA-binding domain missense mutations are found, res...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Demir, Salih, Boldrin, Elena, Sun, Qian, Hampp, Stephanie, Tausch, Eugen, Eckert, Cornelia, Ebinger, Martin, Handgretinger, Rupert, te Kronnie, Geertruy, Wiesmüller, Lisa, Stilgenbauer, Stephan, Selivanova, Galina, Debatin, Klaus-Michael, Meyer, Lüder Hinrich
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939517/
https://ncbi.nlm.nih.gov/pubmed/31073076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.199364
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