Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

Alterations of the tumor suppressor gene TP53 are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia (ALL), TP53 mutations are infrequent but enriched at relapse. As in most cancers, mainly DNA-binding domain missense mutations are found, res...

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Bibliografische gegevens
Gepubliceerd in:Haematologica
Hoofdauteurs: Demir, Salih, Boldrin, Elena, Sun, Qian, Hampp, Stephanie, Tausch, Eugen, Eckert, Cornelia, Ebinger, Martin, Handgretinger, Rupert, te Kronnie, Geertruy, Wiesmüller, Lisa, Stilgenbauer, Stephan, Selivanova, Galina, Debatin, Klaus-Michael, Meyer, Lüder Hinrich
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ferrata Storti Foundation 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939517/
https://ncbi.nlm.nih.gov/pubmed/31073076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.199364
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