Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some contexts. Here, we report that GLS2 is upregulated and essential i...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Lukey, Michael J., Cluntun, Ahmad A., Katt, William P., Lin, Miao-chong J., Druso, Joseph E., Ramachandran, Sekar, Erickson, Jon W., Le, Henry H., Wang, Zhihan-Emily, Blank, Bryant, Greene, Kai Su, Cerione, Richard A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939472/
https://ncbi.nlm.nih.gov/pubmed/31577957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.076
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