Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some contexts. Here, we report that GLS2 is upregulated and essential i...

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Опубликовано в: :Cell Rep
Главные авторы: Lukey, Michael J., Cluntun, Ahmad A., Katt, William P., Lin, Miao-chong J., Druso, Joseph E., Ramachandran, Sekar, Erickson, Jon W., Le, Henry H., Wang, Zhihan-Emily, Blank, Bryant, Greene, Kai Su, Cerione, Richard A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939472/
https://ncbi.nlm.nih.gov/pubmed/31577957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.076
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