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Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation
We previously engineered the tryptophan synthase β-subunit (TrpB), which catalyzes the condensation of l-serine and indole to l-tryptophan, to synthesize a range of noncanonical amino acids from l-serine and indole derivatives or other nucleophiles. Here we employ directed evolution to engineer TrpB...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6939453/ https://ncbi.nlm.nih.gov/pubmed/31747522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b09864 |
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