Distinct IL‐1α‐responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner

How cytokine‐driven changes in chromatin topology are converted into gene regulatory circuits during inflammation still remains unclear. Here, we show that interleukin (IL)‐1α induces acute and widespread changes in chromatin accessibility via the TAK1 kinase and NF‐κB at regions that are highly enr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Weiterer, Sinah‐Sophia, Meier‐Soelch, Johanna, Georgomanolis, Theodore, Mizi, Athanasia, Beyerlein, Anna, Weiser, Hendrik, Brant, Lilija, Mayr‐Buro, Christin, Jurida, Liane, Beuerlein, Knut, Müller, Helmut, Weber, Axel, Tenekeci, Ulas, Dittrich‐Breiholz, Oliver, Bartkuhn, Marek, Nist, Andrea, Stiewe, Thorsten, van IJcken, Wilfred FJ, Riedlinger, Tabea, Schmitz, M Lienhard, Papantonis, Argyris, Kracht, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939198/
https://ncbi.nlm.nih.gov/pubmed/31701553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101533
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