Distinct IL‐1α‐responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner

How cytokine‐driven changes in chromatin topology are converted into gene regulatory circuits during inflammation still remains unclear. Here, we show that interleukin (IL)‐1α induces acute and widespread changes in chromatin accessibility via the TAK1 kinase and NF‐κB at regions that are highly enr...

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Publicado no:EMBO J
Main Authors: Weiterer, Sinah‐Sophia, Meier‐Soelch, Johanna, Georgomanolis, Theodore, Mizi, Athanasia, Beyerlein, Anna, Weiser, Hendrik, Brant, Lilija, Mayr‐Buro, Christin, Jurida, Liane, Beuerlein, Knut, Müller, Helmut, Weber, Axel, Tenekeci, Ulas, Dittrich‐Breiholz, Oliver, Bartkuhn, Marek, Nist, Andrea, Stiewe, Thorsten, van IJcken, Wilfred FJ, Riedlinger, Tabea, Schmitz, M Lienhard, Papantonis, Argyris, Kracht, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939198/
https://ncbi.nlm.nih.gov/pubmed/31701553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101533
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