High-resolution mapping of reciprocal translocation breakpoints using long-read sequencing

Long-read nanopore sequencing enables direct high-resolution breakpoint mapping on balanced carriers of reciprocal translocation. The mean sequencing depth on the translocated chromosomes to achieve accurate mapping of breakpoints ranged from 2.5-fold to 6.2-fold. To speed up determination of the br...

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Udgivet i:MethodsX
Main Authors: Chow, Judy F.C., Cheng, Heidi H.Y., Lau, Estella Y.L., Yeung, William S.B., Ng, Ernest H.Y.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Biochemistry, Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939040/
https://ncbi.nlm.nih.gov/pubmed/31908979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mex.2019.10.028
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