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The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC

Previous studies have shown that oral administration of the NMDAR modulator NYX-2925 alleviates pain in several animal models of neuropathic pain and this appears to be through mPFC, but not spinal, mediated mechanisms. While much is known about the impact of neuropathic pain on NMDAR-mediated signa...

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Dettagli Bibliografici
Pubblicato in:Neurobiol Pain
Autori principali: Morrison, Gladys, Asiedu, Marina N., Priebe, Jessica M., Dunning, Jacqueline, Ghoreishi-Haack, Nayereh, Kroes, Roger A., Bowers, M. Scott, Barth, Amanda L., Cearley, Cassia N., Moskal, Joseph R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938954/
https://ncbi.nlm.nih.gov/pubmed/31909296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ynpai.2019.100039
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