Cross-Packaging and Capsid Mosaic Formation in Multiplexed AAV Libraries

Generation and screening of libraries of adeno-associated virus (AAV) variants have emerged as a powerful method for identifying novel capsids for gene therapy applications. For the majority of libraries, vast population diversity requires multiplexed production, in which a library of inverted termi...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Schmit, Pauline F., Pacouret, Simon, Zinn, Eric, Telford, Elizabeth, Nicolaou, Fotini, Broucque, Frédéric, Andres-Mateos, Eva, Xiao, Ru, Penaud-Budloo, Magalie, Bouzelha, Mohammed, Jaulin, Nicolas, Adjali, Oumeya, Ayuso, Eduard, Vandenberghe, Luk H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938944/
https://ncbi.nlm.nih.gov/pubmed/31909084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.11.014
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