Accurate Titration of Infectious AAV Particles Requires Measurement of Biologically Active Vector Genomes and Suitable Controls

Although the clinical use of recombinant adeno-associated virus (rAAV) vectors is constantly increasing, the development of suitable quality control methods is still needed for accurate vector characterization. Among the quality criteria, the titration of infectious particles is critical to determin...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: François, Achille, Bouzelha, Mohammed, Lecomte, Emilie, Broucque, Frédéric, Penaud-Budloo, Magalie, Adjali, Oumeya, Moullier, Philippe, Blouin, Véronique, Ayuso, Eduard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090651/
https://ncbi.nlm.nih.gov/pubmed/30112419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.07.004
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